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In cellular and mouse PD models, melatonin decreased the polarization of microglia to M1 and increased the anti-inflammatory M2 through upregulation of its ROR receptors that were downregulated with PD induction [389]

A change in GSH/GSSG can reflect tissue injury, metabolic limitation, compensatory defense, treatment response, or a combination of these processes

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(Tinkov et al., 2021) reported that iron overload decreased SIRT -1 gene expression

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